pentobarbital will lessen the extent or impact of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or effect of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to so